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Symbyax Medication For Bipolar Disorder
Symbyax contains a combination of fluoxetine and olanzapine. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Olanzapine is an antipsychotic medication. Symbyax is used to treat depression caused by bipolar disorder (manic depression). Symbyax is sometimes used after at least 2 other medications have been tried without success. This article shall look at Symbax medication for bipolar disorder.
Uses for Symbyax
Symbyax may be prescribed to treat the depressive phase of bipolar disorder. However, Symbyax has not gained much traction and has largely fallen out of favor with psychiatrists since there is no way to titrate the individual ingredients separately.
Instead, t is now much more common to use a combination of Lamictal (lamotrigine) with lithium if lamotrigine alone is not effective. If there is a need for further treatment, the addition of a second-generation medication, such as Vraylar, Latuda, or Rexulti, is often used.
Virtually all patients with this disorder experience the depressive phase, commonly referred to as bipolar depression. People with bipolar disorder typically have three times as many depressed days as they do manic days throughout their illness.
Symbyax has also been FDA-approved for treatment-resistant depression.
Common Side Effects of Symbyax
Common side effects that may go away with time include:
- Appetite increase
- Weight gain
- Dry mouth
- Diarrhea
- Losing or not having the strength
- Sexual difficulties, including decreased interest or inability to orgasm
- Erectile dysfunction
- Twitching
- Joint swelling, redness, or pain
If any of these side effects don’t go away or cause problems, be sure to tell your doctor.
Potentially Serious Side Effects
If you have any of the following side effects, it’s important to contact your doctor right away as you may need medical treatment. These potentially serious side effects include:
- Congestion
- Runny nose
- Cough
- Tingling in your hands or feet
- Dementia
- Delusions
- Body aches or pain
- Gaining weight suddenly
- Difficulty swallowing
- Swelling in your arms, legs, hands, feet, or face
- Difficulty breathing or speaking
- Memory problems
- Chest tightness
- Vision changes
- Irregular heartbeat
- Dizziness
Research on Symbyax
According to a study done around the time the FDA approved Symbyax, Symbyax helped to treat the symptoms of bipolar depression more effectively and at a significantly faster rate than a placebo. In the eight-week studies, patients in the Symbyax group experienced significantly greater improvement in depressive symptoms than patients taking a placebo.
That robust symptom improvement was sustained throughout the entire eight weeks of the study. In addition, Symbyax patients had no statistically greater risk of treatment-emergent mania than patients taking a placebo.
A more recent study that looked at a series of other studies regarding Symbyax also showed its continued effectiveness in treating and keeping the depressive episodes of bipolar disorder at bay.
The only concern was that the side effects may be worse when using Symbyax than they are with other medications, particularly weight gain.
READ ALSO: BIPOLAR DISORDER CYCLES: AN OVERVIEW
Warnings and Precautions About Symbyax
Symbyax carries a black box warning for an increased risk of suicidal thinking and behavior in children, teens, and young adults. Young people should be monitored to watch for increased symptoms of depression and suicidality, particularly during the onset of treatment.
This medication also has a black box warning of an increased risk of mortality in elderly patients with dementia-related psychosis. Symbyax is not approved for use in this population.
Other conditions that may occur after taking this condition include:
- Neuroleptic malignant syndrome
- Hyperglycemia
- Hyperlipidemia
- Serotonin syndrome
- Tardive dyskinesia
- Orthostatic hypertension
- Seizures
- Abnormal bleeding
- Hypotaneremia
To minimize some of these risks, monitoring of fasting blood glucose and lipid profiles is recommended at the initiation and periodically throughout treatment.
If you are considering starting Symbyax, discuss your medical history with your healthcare provider. Be sure to tell your doctor if any of the following apply:
- You are taking Prozac (fluoxetine) or Zyprexa (olanzapine)
- You are taking or plan to take nonsteroidal anti-inflammatory drugs or aspirin
- You are pregnant or plan to become pregnant
- You are breastfeeding or plan to breastfeed
- You are older than 65 and have dementia
- You have high blood sugar, diabetes, or a family history of diabetes
- You have liver problems
- You have seizures
- Do you have high or low blood pressure
- You have heart problems
- You have had a stroke
- You have an enlarged prostate
- You have an eye problem called narrow-angle glaucoma
- You have a stomach problem called paralytic ileus
- You currently smoke
- You drink alcohol
- You exercise often
Always tell your doctor about any medications, supplements, or substances you are currently taking to avoid potentially dangerous drug interactions. This includes other medications that may increase serotonin levels, which can lead to a dangerous condition called serotonin syndrome.
I hope you find this article helpful.
